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KMID : 1144320170490020135
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감염과 화학요법
2017 Volume.49 No. 2 p.135 ~ p.139
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Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies
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Suh Hyeon-Jeong
Kim In-Ho
Cho Joo-Youn
Park Sang-In
Yoon Seo-Hyun
Lee Jeong-Ok
Koh Young-Il
Song Kyoung-Ho
Choe Pyoeng-Gyun
Yu Kyung-Sang
Kim Eu-Suk
Kim Hong-Bin
Bang Soo-Mee
Kim Nam-Joong
Song Sang-Hoon
Park Wan-Beom
Oh Myoung-Don
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Abstract
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The posaconazole tablet formulation was developed to have improved bioavailability compared to the oral suspension. Here, we compared posaconazole plasma concentration (PPC) with the posaconazole oral suspension versus the tablet in Korean patients undergoing remission induction chemotherapy for hematologic malignancies. PPC was measured at 3, 8, and 15 days of treatment with the oral suspension (174 patients) or the tablet (40 patients). At all time-points, mean PPC was significantly higher with the tablet compared to the oral suspension. Our findings suggest that posaconazole tablets generate an optimal PPC earlier and in more patients than the oral suspension among Korean patients.
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KEYWORD
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Posaconazole, Antifungal agents, Tablet, Dosage forms
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